Two growth factors: FGF-2 & FGF-7,
held stable and delivered by an oleosome,
measured in an independent study we cite in full.
Free US shipping. Cancel for a full refund any time before dispatch.
Buildup, excess oil and dryness are the environment problem. The Scalp Reset Serum is a rinse-off exfoliating treatment used once or twice a week to remove buildup and excess sebum and rebalance the scalp, so the nightly serum is applied to a clean, prepared scalp.
FGF·2 and FGF·7, two proteins stabilised as plant-oleosome fusions, one pump nightly. The active was assessed in a 12-week, placebo-controlled study; what it measured is set out in the study section. Individual results vary.
Scalp Reset once or twice a week, Follicular Serum every night, in parallel from day one. With the written guide they form the OF·27 Advanced Protocol: twelve weeks, a baseline photograph at day 0 and a matched one at week 12. You judge the result against your own baseline.
A rinse-off exfoliating treatment, applied to a dry scalp and rinsed after 3–5 minutes. Removes buildup and excess oil and rebalances the scalp: the environment work. One bottle covers all twelve weeks. Included with the Advanced Protocol.
One pump massaged into the scalp before bed and left on overnight. FGF·2 and FGF·7, carried intact by the oleosome fusion. Six weeks per bottle; the studied duration is twelve weeks, two bottles.
A prepared scalp is the starting point. The Scalp Reset Serum removes buildup and excess sebum and rebalances the scalp; the Follicular Serum is applied nightly to that prepared scalp. The two run in parallel from day one.
The duration matches the study. The study of the active took its measurements after twelve weeks of nightly use, in 40 women. One Follicular bottle covers six weeks; twelve weeks is two bottles, which is what the Advanced Protocol contains.
No data beyond week 12. The study ran twelve weeks; we have no measurements of what happens after, with or without continued use. The written guide, included with the Advanced Protocol, covers both serums step by step.
Before the nightly serum goes on, OF·27 prepares the scalp it is applied to: this treatment removes buildup and excess oil and rebalances the scalp, so the Follicular Serum is applied to a clean, prepared surface.
A rinse-off exfoliating treatment, once or twice a week, applied to a dry scalp and rinsed after 3–5 minutes. It removes the buildup and excess sebum that accumulate on the scalp between washes and leaves the scalp clean, hydrated and balanced. One bottle covers the full twelve weeks. The Scalp Reset Serum was not part of the 12-week study.
Ships mid-October, in order of reservation. Bottled to reservations in one small refrigerated run. Nothing ships before then except the written guide, sent by email at purchase. A pre-order can be cancelled for a full refund at any time before dispatch.
The Follicular Serum is the nightly step: FGF·2 and FGF·7, one pump massaged into the scalp, six weeks per bottle. The Advanced protocol runs the full 12 weeks the study measured and adds the Scalp Reset Serum and the written guide.
OF·27 is formulated with FGF·2 and FGF·7, two fibroblast growth factors stabilised as plant-oleosome fusions. Keeping a protein stable in a water-based topical is the hard problem; the oleosome carrier, developed by Core Biogenesis, is the answer to it.
A placebo-controlled study on the active, funded by the active's maker and run by an accredited laboratory. Report open: Abich REL/0504/2026.
Not a single bottle. A twelve-week program with a written guide, a baseline photograph on day 0 and a matched one at week 12.
Keeping two proteins intact in a topical is the hard part, named and explained, not marketed.
FGF·2 and FGF·7 are two signalling proteins the body makes itself; both have been studied in follicle biology for decades.1 OF·27 contains recombinant forms of both, each stabilised as a plant-oleosome fusion.
A 17 kDa heparin-binding signalling protein, one of the most-studied members of the fibroblast growth factor family.2 In OF·27 it is expressed in Camelina seed as an oleosin fusion and declared at 100 ng/mL.
Also known as keratinocyte growth factor (KGF), a member of the same family that is expressed in skin and studied for its action on epithelial cells.3 In OF·27 it is expressed as an oleosin fusion and declared at 500 ng/mL.
The plant's natural energy-storage organelle: a lipid core surrounded by a single phospholipid layer with oleosin proteins embedded in it. Each growth factor is expressed in the seed as an oleosin fusion; the lipid envelope assembles around the protein during seed development.4 The envelope shields the protein from the denaturation that proteins undergo in water-based formulas.5
A free protein in a water-based formula loses activity over time as it denatures. Anchored to the oleosome, the proteins in OF·27 are protected from that loss, which is what lets us declare a concentration on the carton.
Schematic of the rationale, not measured data.
The full report was issued 02 March 2026 by Abich S.r.l., an accredited testing laboratory in Italy. The study was commissioned and funded by Core Biogenesis, the French biotech that developed the active, and tested the active.
The protocol was randomised, single-blind, placebo-controlled. Volunteers did not know which formulation they were applying.
Mean visible hairs per cm² in the active group, measured by C-CUBE® phototrichogram (a scalp-imaging device that counts hairs) at T0, T28, T56, T84. Placebo group: +7.2%, not significant.
Proportion of counted hairs in the growth phase (anagen) versus the resting phase (telogen), read from the same scalp images. Difference between groups at week 12.
Mean diameter of visible hair shafts in the active group, in micrometres (µm), measured by calibrated optical analysis.
Hydration measured by Corneometer® and transepidermal water loss by Nano-Tewameter®. Hydration: difference between groups at week 12. TEWL: change from baseline in the active group.
The study reports a group-mean response to the active. Mean density in the active group rose 33.5%; the distribution spans non-responders to high-responders. Individual results will not match the mean.
The active was tested against its own vehicle placebo; no comparison with any other product was made.
40 healthy female volunteers with telogen effluvium (a common, temporary form of hair shedding) were randomised between active and placebo serum. Investigators measured hair density, anagen/telogen ratio, shaft thickness, scalp hydration and TEWL (water loss) by C-CUBE® Pixience and Courage-Khazaka instruments at four timepoints over eighty-four days. Volunteers were blinded to the formulation. Men and people with other forms of hair loss were not studied.
If your question is not answered here, we are reachable at contact@of27bioscience.com. We answer technical questions in plain prose.
Two recombinant fibroblast growth factors, FGF·2 and FGF·7, stabilised in a plant-derived oleosome carrier, with panthenol, niacinamide and adenosine for scalp conditioning, glycerin, trehalose, xanthan gum and a preservative system. The full ingredient list is on the product page; see also Note 09 · The study.
OF·27 is marketed as a cosmetic. It is not intended to diagnose, treat, cure or prevent any disease. The study we cite was conducted on the active ingredient by a contract laboratory and funded by the active's maker; we report it as published, not as a claim about what OF·27 will do for any individual.
In a randomised, single-blind, placebo-controlled study conducted by Abich S.r.l., an accredited testing laboratory in Italy, between 17 November 2025 and 13 February 2026, commissioned and funded by Core Biogenesis, the French biotech that developed the active. Forty healthy female volunteers with telogen effluvium (a common, temporary form of hair shedding) were split equally between active and placebo arms. Volunteers were not told which formulation they were applying.
At week 12 the active group's mean hair density was 33.5% above baseline (p<0.0001); the placebo group was 7.2% above baseline (not statistically significant).
ABICH REL/0504/2026 · ISSUED 02/03/2026
Four parameters at four timepoints (T0, T28, T56, T84):
Hair density (visible hairs per cm²) by C-CUBE Pixience phototrichogram (a scalp-imaging device that counts hairs). Anagen/telogen ratio (proportion of counted hairs in the growth phase) by the same device. Hair shaft thickness in micrometres by calibrated optical analysis. Scalp hydration by Corneometer® and transepidermal water loss by Nano-Tewameter®.
Active-group figures at week 12: density +33.5%, anagen/telogen +17.0%, shaft thickness +10.6%, hydration +22.2%, TEWL (water loss) −27.2%. The placebo group did not reach statistical significance on density or anagen ratio. Individual results varied.
We cannot tell you. The study reports a group-mean response on the active, in women with telogen effluvium; the individual distribution spans non-responders to high-responders. Note 09 · The study lists the inclusion criteria so a reader can compare her situation to the cohort. If your situation differs, the study tells you less.
We do not extrapolate from a group mean to a personal prediction. The Advanced Protocol carries a results guarantee instead (below).
Advanced Protocol orders only. Send a baseline photograph of your scalp to contact@of27bioscience.com within 7 days of delivery, and a matched photograph (same angle, same light) at week 12. If we cannot see a visible difference between the two, we refund the product price. Claims are opened between the end of week 12 and the end of week 14; shipping, duties and taxes are not refunded; one claim per customer, on a first order placed directly on of27bioscience.com. Full conditions: refund policy.
Everything ships mid-October with the founding batch, in order of reservation, in one shipment. Nothing ships at purchase except the written guide, sent by email. OF·27 is a refrigerated protein formulation bottled to reservations in one small run, so we take orders before bottling. A pre-order can be cancelled for a full refund at any time before dispatch.
A plant-derived lipid body. Certain oilseeds naturally produce them as energy storage. When a growth factor protein is expressed in the seed alongside an oleosome, the two fuse during seed development.
The fused complex survives extraction and formulation. Proteins denature in solution; the oleosome lipid envelope keeps them intact in the bottle.
One pump applied nightly, directly to the scalp (not the lengths), focusing on areas where hair appears thinner. Each pump delivers roughly 1 mL (about 1 cc), so one 50 mL airless pump bottle covers six weeks of nightly use. Massage into the scalp for at least thirty seconds, then leave on overnight; do not rinse. The airless dispenser keeps each dose isolated from air until application.
The study ran twelve weeks; that duration is two consecutive bottles, which is what the Advanced Protocol contains. The Scalp Reset Serum, included with the Advanced Protocol, is a rinse-off exfoliating treatment used once or twice a week on a dry scalp and rinsed after 3–5 minutes.
We recommend refrigerating OF·27 at 2 to 8 °C. The actives are proteins, and cold storage best preserves them, so it is the conservative choice rather than a strict requirement. The formulation tolerates room temperature without harm, whether during application or in transit; where convenient, return the bottle to the fridge after use.
Do not freeze. Freezing ruptures the oleosome carrier and irreversibly denatures the proteins. A bottle that has frozen should not be used.
FGF·2 and FGF·7 are signalling proteins that have been studied in dermatology for decades. In the 12-week placebo-controlled study of the active, volunteers were screened for irritated skin, active dermatological pathology, and recent topical medication; no serious adverse events were reported.
As with any topical, stop use if irritation occurs and tell us at contact@of27bioscience.com.
Yes. The study cohort was all-female (n=40), recruited specifically for telogen effluvium, so the figures on this site describe that cohort. The formulation and the protocol are the same for men and women.
In the United States, under ISO 22716, the cosmetics manufacturing standard. Each bottle carries a batch identifier, manufacturing date, and expiry.
Apply to a clean, towel-dried scalp before any other leave-in product. We have not tested interactions with other products. If you use a prescription treatment, ask your prescriber before adding anything.
OF27 Bioscience does not commission animal testing. The study cohort was human, and the pre-clinical work on the active used in vitro cell culture. Ingredient suppliers' historical testing is outside our control.
The study is published in the International Journal of Clinical & Experimental Dermatology (IJCED) ⇗. It sets out the protocol, the cohort criteria, the endpoint definitions, the results tables, the statistical summaries, and the adverse-event record. For a plain-language walkthrough, see Note 09 · The study.
Funding disclosure: the study was commissioned and funded by Core Biogenesis, the supplier of the active ingredient, and conducted by Abich S.r.l.
The works below are the background literature for the biology described on this page: the study of FGF·2 and FGF·7 in follicle biology, the structure of the hair cycle, and the principle of carrying proteins on plant oil bodies. They do not report on OF·27 itself: the outcomes shown above are from the Abich study of the active (REL/0504/2026), cited in full in the Results section.
Nothing reserved yet.
The founding batch ships mid-October, in order of reservation.
— The recommended protocol · results guarantee Advanced protocol The full 12 weeks: 2 bottles of Follicular Serum, with the Scalp Reset Serum and the protocol guide included. $195Introductory pre-order price Reserve the Advanced protocolFive questions, two minutes, and we'll tell you which protocol fits and why.